Marie Gernigon

 

 

Marie GERNIGON, Ph.D.

Maître de Conférences | Associate professor

Faculté des sciences du sport de l'Université Paris Sud

Bât. 335 rue Pierre de Coubertin

91405 Orsay cedex I FRANCE

Tel. :+33 (0) 169 158 111

Email : marie.gernigon @ u-psud.fr

Website : http://marie.gernigon.fr/

 

 Thématique de recherche [FR]

Mon travail s’intéresse principalement au déficit en dioxygène (O2) à l’effort comme facteur limitant de l’exercice chez des participants entraînés ou malades.

En effet, malgré l'importance du plateau de la consommation maximale en O2 (i.e., VO2max ) pour objectiver le caractère maximal d’une épreuve d’effort incrémentée, la littérature rapporte des dissonances dans sa prévalence i.e., de 0 à 90% en fonction des études (1–4). Aussi, une partie de mes travaux s’intéressent aux facteurs limitants la performance maximale (i.e., ) chez la personne saine et entraînée.

Je m’intéresse également aux conséquences fonctionnelles d’un déficit en O2 à la marche chez le patient vasculaire. En effet, le patient présentant une altération de la fonction artérielle périphérique peut présenter une gêne fonctionnelle à la marche en raison d’une ischémie induite à l’effort (Artériopathie Oblitérante des Membres inférieurs, AOMI) (5–7). L’évaluation de la Distance de Marche Maximale (DMM) représente un enjeu primordial puisqu’une DMM inférieure à 300 mètres est en faveur d’une revascularisation (8). Aussi, une autre partie de mes travaux s’intéressent à l’évaluation de la marche des patients artériopathes au moyen de méthodologies innovantes e.g., tests de marche en milieu écologique avec un GPS (Géo-Positionnement Satellitaire) et tests de marche sur tapis roulant avec une mesure de la pression transcutanée en dioxygène (TcPO2).

Research Interest [EN]

My work focused on the consequences of dioxygen (O2) deficit as a limiting factor of exercise in trained and diseased participants.

Despite the importance to characterize the plateau of maximal oxygen uptake (i.e., i.e., VO2max ) in order to state that the exercise is maximal, the literature reports dissonances in its prevalence i.e., 0 to 90% depending on studies (1–4). The origin of this variability in  plateau prevalence is multifactorial. Thus, one part of my work aims to assess the factors limiting maximum performance in the healthy and trained participants.

I am also interested in the functional consequences of an O2 deficit in walking. Indeed, the patient with peripheral arterial dysfunction (Peripheral Arterial Diseased, PAD) may exhibit walking functional discomfort due to exercise induced ischemia (5–7). The evaluation of the Maximum Walking Distance (MWD) represents a crucial issue since a MWD of less than 300 meters is in favor of a revascularization (8). Therefore, the other aim of my work is to test the validity of innovative methodologies based on Global Positioning System (GPS) and Transcutaneous Pressure in Oxygen (TcPO2) during a treadmill test with respect to the assessment of the functional limitation in PAD patients.

 

Références

1- Doherty M, Nobbs L, Noakes TD. Low frequency of the “plateau phenomenon” during maximal exercise in elite British athletes. Eur J Appl Physiol. 2003; 89(6):619–23.

2- Gordon D, Hopkins S, King C, Keiller D, Barnes RJ. Incidence of the Plateau at VO2max is Dependent on the Anaerobic Capacity. International Journal of Sports Medicine. 2011 Jan; 32(01):1–6.

 3- Astorino TA, White AC. Assessment of anaerobic power to verify VO2max attainment. Clinical Physiology and Functional Imaging. 2010 Jul 1; 30(4):294–300.

 4- Rivera-Brown AM, Frontera WR. Principles of exercise physiology: responses to acute exercise and long-term adaptations to training. PM R. 2012 Nov; 4(11):797–804.

 5- Resnick HE, Lindsay RS, McDermott MM, Devereux RB, Jones KL, Fabsitz RR, et al. Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart Study. Circulation. 2004; 109(6):733–9.

 6- McDermott MM, Liu K, Ferrucci L, Tian L, Guralnik JM, Liao Y, et al. Decline in functional performance predicts later increased mobility loss and mortality in peripheral arterial disease. J Am Coll Cardiol. 2011; 57(8):962–70.

7- McDermott MM, Liu K, Ferrucci L, Tian L, Guralnik JM, Liao Y, et al. Greater sedentary hours and slower walking speed outside the home predict faster declines in functioning and adverse calf muscle changes in peripheral arterial disease. J Am Coll Cardiol. 2011; 57(23):2356–64.

8- Dormandy JA, Rutherford RB. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC). J Vasc Surg. 2000; 31(1 Pt 2):S1–296.

 

Publications indexées dans des revues à comité de lecture | Peer reviewed publications

Klonizakis, M., Bianchi S.M., Gernigon, M., Abraham, P., Nawaz, S. Real-Life Adaptations in Walking Patterns in Patients with Established Peripheral Arterial Disease Assessed Using a Global Positioning System in the Community: A Cohort Study. Clinical Physiology and Functional Imaging. Accepted [Quartile 2016: 3; IF 2016: 2.300]

de Müllenheim, P.-Y., Chaudru, S., Emily, M., Gernigon, M., Mahé, G., Bickert, S., Prioux, J., Noury-Desvaux, B., Le Faucheur, A. Using GPS, accelerometry and heart rate to predict outdoor graded walking energy expenditure. Journal of Science and Medicine in Sport. Epub ahead of print [Quartile 2016: 1; IF 2016: 3.857] Link

Gordon, D., Gernigon, M., Baker, J., Merzbach, V., Scruton, A. The effects of non-contingent feedback on the incidence of plateau at VO2max. Journal of Sports Science and Medicine. 2017; 16: 105-111 [Quartile 2016: 2; IF 2016: 1.797] Link

de Müllenheim, P.Y., Chaudru, S., Gernigon, M., Mahé, G., Bickert, S., Prioux, J., Noury-Desvaux, B. and Le Faucheur, A. Accuracy of a low-cost global positioning system receiver for estimating grade during outdoor walking. Physiological Measurement. 2016; 37: 1741–1756 [Quartile 2016: 3  IF 2016: 2.058] Link

de Müllenheim, P.Y., Dumond, R., Gernigon, M., Mahé, G., Lavenu, A., Bickert, S., Prioux, J., Noury-Desvaux, B., Le Faucheur, A. Predicting metabolic rate during level and uphill outdoor walking using a low-cost GPS receiver. Journal of Applied Physiology. 2016; 121(2):577-88 [Quartile 2016: 1; IF 2016: 3.351] Link

Gernigon, M., Fouasson-Chailloux, A., Colas-Ribas, C., Noury-Desvaux, B., Le Faucheur, A., Abraham, P. Test-retest Reliability of GPS derived Measurements in Patients with Claudication. European Journal of Vascular and Endovascular Surgery. 2015; 50(5):623-9 [Quartile 2015: 1; IF 2015: 2.912] Link

Gernigon, M., Le Faucheur, A., Fradin, D., Noury-Desvaux, B., Landron, C., Mahé, G., Abraham, P. Global positioning system (GPS) use in the community to evaluate improvements in walking after revascularization: A prospective multicenter study with six-month follow-up in patients with peripheral arterial disease. Medicine. 2015; 94(18):e838. [Quartile 2015: 1; IF 2015: 4.256] Link

Gordon, D., Caddy, O., Merzbach, V., Gernigon, M., Baker, J., Scruton, A., Keiller, D., Barnes, R. Prior Knowledge of Trial Number Influences the Incidence of Plateau at VO2max. Journal of Sports Science and Medicine., 2015; (14): 47-53. [Quartile 2015: 2; IF 2015: 2.000] Link

Gordon, D., Wood, M., Porter, A., Vetrivel, V., Gernigon, M., Caddy, O., Merzbach, V., Keiller, D., Baker, J., Barnes, R. Influence of blood donation on the incidence of plateau at VO2max. European Journal of Applied Physiology. 2014; 114(1):21-27. [Quartile 2014: 1; IF 2014: 1.430] Link

Gernigon, M., Le Faucheur, A., Noury-Desvaux, B., Mahe, G., Abraham, P.; Post-GPS Study Coinvestigators Group. Applicability of global positioning system for the assessment of walking ability in patients with arterial claudication. Journal of Vascular Surgery. 2014; 60(4): 973-981. [Quartile 2014: 1; IF 2014: 3.021] Link

Tew, G., Copeland, R., Le Faucheur, A., Gernigon, M., Nawaz, S., Abraham, P. Feasibility and validity of self-reported walking capacity in patients with intermittent claudication. Journal of Vascular Surgery. 2013; 57(5):1227-34. [Quartile 2013: 1; IF 2013: 2.980] Link

Gernigon, M., Marchand, J., Ouedraogo, N., Leftheriotis, G., Piquet, JM., Abraham, P. Proximal ischemia is a frequent cause of exercise-induced pain in patients with a normal ankle to brachial index at rest. Pain Physician. 2013; 16(1):57-64. [Quartile 2013: 1; IF 2013: 4.776] Link

Abraham, P., Noury-Desvaux, B., Gernigon, M., Mahé, G., Sauvaget, T., Leftheriotis, G., Le Faucheur, A. The inter- and intra-unit variability of a low-cost GPS data logger/receiver to study human outdoor walking in view of health and clinical studies. PLoS One. 2012; 7(2):e31338. [Quartile 2012: NA; IF 2012: 3.730] Link

Gordon, D., Mehter, M., Gernigon, M., Caddy, O., Keiller, D., Barnes, R. The effects of exercise modality on the incidence of plateau at VO2max. Journal of Clinical Physiology and Functional Imaging. 2012; 32(5):394-399. [Quartile 2012: NA; IF 2012: 1.33] Link

Gordon, D., Schaitel, K., Pennefather, A., Gernigon, M., Keiller, D., Barnes, R. The incidence of plateau at VO2max is affected by a bout of prior-priming exercise. Clinical Physiology and Functional Imaging. 2012; 32(1):39-44. [Quartile 2012: NA; IF 2012: 1.33] Link