Manh-Cuong Do

Professeur des Universités

manh-cuong.do @ u-psud.fr (manh-cuong.do @ u-psud.fr)

Tel : +33 (0)1 69 15 37 47

Fax :+33 (0)1 69 15 62 22

Université Paris-Sud

Bât. 335. Bureau : Direction Recherche

91405 Orsay Cedex

Thématiques de Recherche

Dans l’étude sur les interactions entre les contraintes du contrôle de l’équilibre postural et la performance motrice, nous nous sommes intéressés au contrôle de l’équilibre au cours de la marche, chez le jeune adulte, l’adulte âgé, et certains types de patients. Nous avons mis en évidence un indice biomécanique permettant une quantification de l’état du processus de contrôle de l’équilibre. Cet indice est basé sur la magnitude de freinage de la chute qui intervient à chaque phase pendulaire de la marche. Chez l’adulte âgé cet indice est plus faible que chez les jeunes, voire nul (étude en collaboration avec le Dr. RKY Chong, Dept Phys Th, Med Coll Georgia, article en préparation). Cet indice a pu être également testé dans une étude en collaboration avec le Centre d’Investigation Clinique des Maladies Nerveuses de l’Hôpital Salpêtrière (Pr Y Agid, Dr M-L Welter) sur des patients parkinsoniens (OFF/ON médicament, ou stimulation électrique profonde, un article publié et un soumis à Brain). Nos investigations sur le contrôle de l’équilibre et de son versant négatif, la chute, ont fait que nous avions été sollicité à participer au Projet AILISA (STIC-Santé, Responsable Dr N Noury, TIMC, Grenoble) et au projet NEUROMAD (Responsable ROBOSOFT S.A et V Pasqui, Lab Robotique de Paris, UPMC Paris 6). Dans ce dernier projet notre contribution portait l’analyse du mouvement « se lever et marcher ». Ce modèle expérimental servira à identifier les facteurs aussi bien physiques, physiologiques que cognitifs qui permettraient d’expliquer pourquoi les personnes âgées ont des difficultés de se lever et marcher (souvent elles retombent sur leur siège). C’est l’objet d’une Thèse qui vient de démarrer.

Research interests

Balance control underlies any movement carried out in a gravity field. When it is affected by different ways (eg. ontogenesis, ageing, pathology), movement performance is also affected, especially during locomotion. We focused on the biomechanical and somato-sensori mechanisms underlying the “anticipatory” balance control and “compensatory reactions” to postural perturbations. Our Lab is well equipped to investigate this complex problem (force platform, 0.9 x 1.80 m; accelerometers; goniometers ...; electronic video; wireless EMG; magnetic stimulation ...). In connection with hospitals (Salpêtrière Hosp. and Bicêtre Hosp.) we can provide test for patients. Actually, several national and international collaborations are running (Dr R. Katz, Fr.; Prof N. Noury, Fr.; Dr V. Pasqui, Fr.; Prof P. Portero, Fr.; Prof M Schieppati, It.; Prof C. Pai, USA; Dr RKY Chong, USA).

Publications (depuis 2005)

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Schieppati M, Honeine JL, Do MC, Crisafulli O. (2016) On the origin of the mediolateral displacement of the centre of pressure during gait initiation. Ann Phys Rehabil Med. 59S:e121-e122. doi: 10.1016/j.rehab.2016.07.275.

Honeine JL, Schieppati M, Crisafulli O, Do MC. (2016) The Neuro-Mechanical Processes That Underlie Goal-Directed Medio-Lateral APA during Gait Initiation.Front Hum Neurosci. 10:445. doi: 10.3389/fnhum.2016.00445.

Cusin E, Do MC, Rougier PR. (2016) How does wearing a lumbar orthosis interfere with gait initiation? Ergonomics. 12:1-7. [Epub ahead of print]

Cottin F, Malcurat V, Zorgati H, Prieur F, Labsy Z, Do MC, Gagey O, Collomp K. (2015) Effect of oral glucocorticoid intake on autonomic cardiovascular control. Springerplus. 4:622. doi: 10.1186/s40064-015-1378-8.

Dommes A, Lay TL, Vienne F, Dang NT, Beaudoin AP, Do MC. (2015) Towards an explanation of age-related difficulties in crossing a two-way street. Accid Anal Prev. 85:229-38. doi: 10.1016/j.aap.2015.09.022.

Delafontaine A, Honeine JL, Do MC, Gagey O, Chong RK. (2015) Comparative gait initiation kinematics between simulated unilateral and bilateral ankle hypomobility: Does bilateral constraint improve speed performance? Neurosci Lett. 603:55-9. doi: 10.1016/j.neulet.2015.07.016.

Collomp K, Zorgati H, Cottin F, Do MC, Labsy Z, Gagey O, Lasne F, Prieur F, Collomp R. (2015) Time-course of prednisone effects on hormonal and inflammatory responses at rest and during resistance exercise. Horm Metab Res. 47(7):516-20. doi: 10.1055/s-0034-1395608.

Hamaoui A, Hudson AL, Laviolette L, Nierat MC, Do MC, Similowski T. (2014) Postural disturbances resulting from unilateral and bilateral diaphragm contractions: a phrenic nerve stimulation study. J Appl Physiol (1985). 117(8):825-32. doi: 10.1152/japplphysiol.00369.2014.

Zorgati H, Prieur F, Vergniaud T, Cottin F, Do MC, Labsy Z, Amarantini D, Gagey O, Lasne F, Collomp K. (2014) Ergogenic and metabolic effects of oral glucocorticoid intake during repeated bouts of high-intensity exercise. Steroids. 10-5. doi: 10.1016/j.steroids.2014.04.008.

Bonnet CT, Cherraf S, Do MC. (2014) Methodological requirement to analyze biomechanical postural control mechanisms with two platforms. Hum Mov Sci. 35:94-103. doi: 10.1016/j.humov.2014.03.007.

Honeine JL, Schieppati M, Gagey O, Do MC. (2014) By counteracting gravity, triceps surae sets both kinematics and kinetics of gait. Physiol Rep. 2(2):e00229. doi: 10.1002/phy2.229.

Collomp R, Labsy Z, Zorgati H, Prieur F, Cottin F, Do MC, Gagey O, Lasne F, Collomp K. (2014) Therapeutic glucocorticoid administration alters the diurnal pattern of dehydroepiandrosterone. Endocrine. 46(3):668-71. doi: 10.1007/s12020-013-0122-9.

Maillot P, Perrot A, Hartley A, Do MC. (2014) The braking force in walking: age-related differences and improvement in older adults with exergame training. J Aging Phys Act. 22(4):518-26. doi: 10.1123/japa.2013-0001.

Demain A, Westby GW, Fernandez-Vidal S, Karachi C, Bonneville F, Do MC, Delmaire C, Dormont D, Bardinet E, Agid Y, Chastan N, Welter ML. (2014) High-level gait and balance disorders in the elderly: a midbrain disease? J Neurol. 261(1):196-206. doi: 10.1007/s00415-013-7174-x.

Ille A, Selin I, Do MC, Thon B. (2013) Attentional focus effects on sprint start performance as a function of skill level. J Sports Sci. 31(15):1705-12. doi: 10.1080/02640414.2013.797097.

Memari S, Do MC, Le Bozec S, Bouisset S. (2013) The Consecutive Postural Adjustments (CPAs) that follow foot placement in single stepping. Neurosci Lett. 543:32-6. doi: 10.1016/j.neulet.2013.02.061.

Diakhaté DG, Do MC, Le Bozec S. (2013) Effects of seat-thigh contact on kinematics performance in sit-to-stand and trunk flexion tasks. J Biomech ;46(5):879-82. doi: 10.1016/j.jbiomech.2012.12.022.

Honeine JL, Schieppati M, Gagey O, Do MC. (2013) The functional role of the triceps surae muscle during human locomotion. PLoS One. 8(1):e52943. doi: 10.1371/journal.pone.0052943.

Sozzi S, Honeine JL, Do MC, Schieppati M. (2013) Leg muscle activity during tandem stance and the control of body balance in the frontal plane. Clin Neurophysiol. 124(6):1175-86. doi: 10.1016/j.clinph.2012.12.001.

Caderby T, Dalleau G, Leroyer P, Bonazzi B, Chane-Teng D, Do MC. (2013) Does an additional load modify the Anticipatory Postural Adjustments in gait initiation? Gait Posture. 37(1):144-6. doi: 10.1016/j.gaitpost.2012.06.012.

Labsy Z, Prieur F, Le Panse B, Do MC, Gagey O, Lasne F, Collomp K. (2013) The diurnal patterns of cortisol and dehydroepiandrosterone in relation to intense aerobic exercise in recreationally trained soccer players. Stress. 16(2):261-5. doi: 10.3109/10253890.2012.707259.

Sozzi S, Do MC, Monti A, Schieppati M. (2012) Sensorimotor integration during stance: processing time of active or passive addition or withdrawal of visual or haptic information. Neuroscience. 212:59-76. doi: 10.1016/j.neuroscience.2012.03.044.

Yiou E, Do MC. (2011) Effects of medio-lateral postural perturbation induced by voluntary arm raising on the biomechanical organization of rapid step initiation. Motor Control. 15(4):507-24.

Yiou E., & Do M.C. (2010) Control of medio-lateral stability during rapid voluntary step initiation with preferred and non-preferred leg: is it symmetrical? Gait and Posture.

Yiou E., Deroche T, Do MC, Woodman T. (2010) Influence of fear of falling on anticipatory postural control ofmediolateral stability during rapid leg flexion. European Journal of Applied Physiology.

Chong RK, Chastan N, Welter ML, Do MC. Age-related changes in the center of mass velocity control during walking. Neurosci Lett. 2009 Jul 10; 458(1):23-7.

Chastan N, Westby GW, Yelnik J, Bardinet E, Do MC, Agid Y, Welter ML. Effects of nigral stimulation on locomotion and postural stability in patients with Parkinson's disease. Brain. 2009 Jan; 132(Pt 1):172-84.

Chastan N, Do MC, Bonneville F, Torny F, Bloch F, Westby GW, Dormont D, Agid Y, Welter ML. Gait and balance disorders in Parkinson's disease: impaired active braking of the fall of centre of gravity. Mov Disord. 2009 Jan 30; 24(2):188-95.

Bouisset S, Do MC. Posture, dynamic stability, and voluntary movement. Neurophysiol Clin. 2008 Dec; 38(6):345-62

Do MC, Chong RK. Balance recovery from a forward fall: developmental aspects of sensorimotor organization and the role of supraspinal control. Neurosci Lett. 2008 Sep 19; 442(3):300-4.

Toussaint Y, Do MC, Fagard J. What are the factors responsible for the deviation in stepping on the spot? Neurosci Lett. 2008 Apr 11; 435(1):60-4.

Welter ML, Do MC, Chastan N, Torny F, Bloch F, du Montcel ST, Agid Y. Control of vertical components of gait during initiation of walking in normal adults and patients with progressive supranuclear palsy. Gait Posture. 2007 Sep; 26(3):393-9.

Charrois O, Do MC, Anract P, Maton B, Courpied JP. [Electromyographic study of stretch reflexes in the normal and prosthetic hip] Rev Chir Orthop Reparatrice Appar Mot. 2006 Feb;92(1):33-9. French.

Hamaoui A, Do MC, Bouisset S. Postural sway increase in low back pain subjects is not related to reduced spine range of motion. Neurosci Lett. 2004 Mar 4; 357(2):135-8.

Michel V, Do MC*, Chong RKY. The strategies to regulate and to modulate the propulsive forces during gait initiation in lower limb amputees. Exp Brain Res 2004 Oct; 158(3):356-65. *correctif sur http://dx.doi.org/10.1007/s00221-004-2001-3